First and foremost, if you are not pleased with your doctor, look for another one. You can find a listing of doctors who specialize in menopause on the North American Menopause Society's website which is <A HREF="
www.menopause.org." TARGET=_blank>
www.menopause.org.</A><BR>The rapid change in response makes it seem something in your body has changed. The acne sounds like a sudden increase in androgens and the loss of a cup size makes it sound like the estrogen suddenly stopped getting into the bloodstream. It is possible that some other problem started and either the thyroid or the adrenal glands have changed their hormone production. An increase in insulin could also increase androgens.<BR>You may also want to try a new batch of patches. If that doesn't work see an endrocrinologist. You might consider getting blood tests for an 8am fasting cortisol and insulin level, a 17-OH progesterone, a DHEA-S,delta-4-androstenedione, Free Testosterone and a thyroid stimulating hormone and T4. There could be a problem outside of your reproductive hormones. Those problems can affect mood as well. Also, you should report to your doctor if you are losing hair, gaining weight, having swelling of the hands, face and feet, and a number of other historical facts, and get a good physical exam. But for now, ask your doctor to provide you with a new patch, and if that doesn't work in a week or two, see an endocrinologist to evaluate your adrenal, thyroid and pancreas. I hope that this helps and directs you on the path to feeling better.